Harnessing MultiTME: Multi-Sample, Multimodal Spatial to Model the Tumor Microenvironment
June 24, 2025
Single-Cell and Spatial
- A hierarchical Bayesian model jointly models and aligns spatial transcriptomic, spatial proteomic, and single-cell sequencing data on matched tissues MultiTME learns unified transcriptional and proteomic cell type profiles
- Spatial modeling enables refinement of pathologist H&E annotations and better detection of tertiary lymphoid sites in premalignant lung cancer
- You will learn how MultiTME ntegrates spatial transcriptomic, spatial proteomic, and single-cell sequencing data to create unified cell type profiles enhancing detection of tertiary lymphoid sites in premalignant lung cancer.
