While the genome is static, the epigenome is dynamic; shaped by environment and behavior, influencing disease onset and progression.

This track will cover new advances in epigenetic biomarkers, diagnostics and therapies, and explore how epigenetics is driving novel approaches in research and clinical innovation. 

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11:30
  1. Unraveling Histone Modification Machinery: Structural Mechanisms of Epigenetic Regulation in Cancer
    Epigenetics Stage
    30 mins
    Revealing the structural mechanisms of histone-modifying complexes  Understanding how epigenetic machinery controls gene regulation  Insights into chromatin regulation and implications for cancer biol …
    Speakers
    Speaker image for Evan Worden
    Evan Worden, Assistant Professor - Van Andel Institute
12:00
  1. Sponsored Slot Available
    Epigenetics Stage
    30 mins
12:30
  1. Stem Cell States in Neural Regeneration
    Epigenetics Stage
    30 mins
    Olfactory epithelial stem cells give rise to multiple cell types during development and after injury  Single cell profiling reveals multiple epigenetic states of olfactory stem cells during homeostasi …
    Speakers
    Speaker image for Whitney Heavner
    Whitney Heavner, Scientist - National Institute of Neurological Disorders and Stroke (NINDS)
14:10
  1. Taming The Unknown: Pragmatic Epigenetic Approaches in Cancer Risk Assessment and Treatment
    Epigenetics Stage
    30 mins
    Cancer is a genetic and epigenetic disease. Epigenetic modifications, especially DNA methylation, selected histone modifications, miRNAs, and non-coding RNAs play a role in carcinogenesis and have bee …
    Speakers
    Speaker image for Mukesh Verma
    Mukesh Verma, Chief, Cancer Epidemiology - Genomics Research Program, NCI (NIH)
14:40
  1. Long-Read Epigenetics and the Hidden Regulation of mtDNA
    Epigenetics Stage
    30 mins
    Applying long-read sequencing and mt-fiberseq to uncover epigenetic-like regulation across thousands of mitochondrial genomes per cell Tracking activation, replication, and heterogeneity of mtDNA copi …
    Speakers
    Speaker image for Stefan Isaac
    Stefan Isaac, Assistant Professor, Biochemistry and Cell Biology - Boston University
15:10
  1. Epigenetic Signatures Linking Alzheimer’s Genetic Risk and Alcohol Use Disorder
    Epigenetics Stage
    30 mins
    We present shared and distinct genetic and epigenetic mechanisms across five substance use disorders that shape patterns of comorbidity.   Building on this broader framework and given the known links …
    Speakers
    Speaker image for Gita Pathak
    Gita Pathak, Assistant Professor - Icahn School of Medicine at Mount Sinai
16:10
  1. The Promise and Peril of Targeting Epigenetics through the Large-Scale COSMOS Randomized Clinical Trial to Improve Healthspan and Prevent Disease
    Epigenetics Stage
    30 mins
    Provides background and context on the distribution of epigenetic clocks in large-scale longitudinal cohorts of older adults, as well as the extent to which they change over time. Presents emerging ev …
    Speakers
    Speaker image for Howard Sesso
    Howard Sesso, Associate Director, Division of Preventive Medicine - Brigham and Women's Hospital
16:40
  1. DropC Allows Scalable and Multimodal Profiling of Genetic and Non-Genetic Determinants of Human Leukemia
    Epigenetics Stage
    30 mins
    Deciphering cancer progression and therapeutic response requires studying both genetic and non-genetic determinants of tumour heterogeneity. To address this, we developed DropC, a high-throughput sing …
    Speakers
    Speaker image for Giovanni Gambi
    Giovanni Gambi, Postdoctoral Researcher - NYU Langone Health
17:10
  1. AI for Single-Cell Regulatory Genomics
    Epigenetics Stage
    30 mins
    Speakers
    Speaker image for Christina Leslie
    Christina Leslie, Principal Investigator - Memorial Sloan Kettering Cancer Center
11:30
  1. DNA Topology, Chromatin Structure and Therapeutic Control
    Epigenetics Stage
    30 mins
    Speakers
    Speaker image for Taekjip Ha
    Taekjip Ha, Professor - Harvard Medical School and Boston Children’s Hospital
12:00
  1. Sex-Specific Epigenetic Regulation of Neurodevelopment via Stress Signalling and Transposons
    Epigenetics Stage
    30 mins
    Discovery of a stress-hormone receptor linked to epigenetic regulation of neuronal development in rats   Evidence that this pathway regulates dendrite growth in a sex-specific manner   Suggests a mech …
    Speakers
    Speaker image for Richard Hunter
    Richard Hunter, Associate Professor - University of Massachusetts Boston
12:30
  1. Rewriting the epigenetic playbook: targeting epigenetic drivers of childhood cancer.
    Epigenetics Stage
    30 mins
    Epigenetic dysregulation as a central driver of cancer, particularly in pediatric disease.  Rethinking therapeutic strategy: rational combinations, epigenetic-immune synergy, and new directions.  Targ …
    Speakers
    Speaker image for Michael Koldobskiy
    Michael Koldobskiy, Assistant Professor of Oncology - Johns Hopkins University School of Medicine
14:00
  1. Single-cell 3D Genome Organization in Leukemia with DROP-C
    Epigenetics Stage
    30 mins
    DROP-C, a novel single-cell multi-modal assay for 3D genome organization  A novel deep learning framework for Hi-C data resolution augmentation  Single-cell 3D-omics in leukemia 
    Speakers
    Speaker image for Guido Barzaghi
    Guido Barzaghi, Postdoctoral Fellow in the Tsirigos Lab - NYU Grossman School of Medicine
14:30
  1. Structure and Function of ATP-Dependent Chromatin Remodeling Complexes in Health and Disease
    Epigenetics Stage
    30 mins
    Structural and mechanistic insights into how ATP-dependent chromatin remodeling complexes (including SWI/SNF/BAF) regulate genome accessibility and transcriptional control  The role of chromatin remod …
    Speakers
    Speaker image for Cigall Kadoch
    Cigall Kadoch, Professor - Dana-Farber Cancer Institute
15:00
  1. How Enhancer Mutations Drive Ovarian Cancer Through RNA-Mediated Epigenetic Regulation
    Epigenetics Stage
    30 mins
    The noncoding genome problem — most cancer-associated variants lie outside genes, limiting interpretation and clinical translation.  Enhancer RNAs as active epigenetic regulators — eRNAs control mRNA …
    Speakers
    Speaker image for Natalia Benova
    Natalia Benova, PhD Candidate - Leeds Beckett University