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Polyploid Cardiomyocytes Define Niche-Specific Transcriptional States in the Mammalian Heart
- To better understand cardiomyopathy, we assembled a >4.5 million cell dataset across human, mouse, rat and fetal hearts
- Spatial transcriptomics enable us to define cardiomyocyte states on the niche-, cell- and subcellular-level
- We identified polyploid (genome-doubled) cardiomyocytes as a distinct cell state that rewires its metabolic and chromatin landscapes to recapitulate a fetal-like signature.
- Inhibiting TNIK, a kinase specifically expressed in polyploid cardiomyocytes, improves post-infarct heart remodeling in rats
