I am the Chief of Breast Surgery and Co-leader of the Breast Cancer Program at the Cleveland Clinic. I have a joint appointment in Surgery and Cancer Biology. I lead clinical trials and am PI of a translational research laboratory that studies circulating tumor cells in breast cancer and rare, aggressive diseases such as inflammatory breast cancer. I have a position that allows me to devote 40% of my effort to cancer research studies. My lab focuses on translational research related to breast cancer tumor biology and biomarkers of prediction of response to therapy. We recently established a patient derived xenograft model for inflammatory breast cancer. Much of my research program is aimed at studying circulating tumor cells and circulating tumor DNA as a liquid biopsy in cancer. I have had foundation grant and industry support for my research. I have served as an I-SPY2 clinical trials investigator for more than 10 years, including serving as PI at two institutions. My lab has relocated to the Cleveland Clinic and we look forward to building a robust research program in clinical-translational research to benefit the large patient population treated at our institution.