Sasha Singh

Dr Singh is Assistant Professor of Medicine at Harvard Medical School and Director of Proteomics Research at the Center for Interdisciplinary Cardiovascular Sciences at Brigham and Women’s Hospital. In 2012, she established a proteomics program within an academia-industry research paradigm aimed at identifying novel biologic first-in-class drugs to treat cardiovascular diseases. Dr. Singh was the first to apply high-resolution, high-accuracy mass spectrometry to monitor protein turnover in humans. Her work has contributed to a paradigm shift in our understanding of “good HDL-cholesterol particle” metabolism, providing insight on why HDL-cholesterol-raising trials have failed to reduce major adverse cardiovascular events. Dr. Singh also actively investigates the effects of various post-translational modifications on protein function. Her lab has extensive expertise in developing bench-to-instrument workflows for ADP-ribosylation proteomics, advancing the study of this critical modification and its role in cellular processes.