The Proteomics Stage will help you overcome challenges to derive meaningful clinical insights from large proteomics datasets, including single-cell and spatial proteomics, scaling clinical proteomics and advancing precision medicine through innovative technologies.
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Proteomics Stage30 minsProgress and current pitfalls of high-throughput proteomics How can proteomics fill many of the voids left by genomics research? How are uk biobank cohort studies supporting disease risk assessment & ...
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Proteomics Stage30 minsIntroduction to Next-Gen Protein Sequencing™ (NGPS™) on Platinum® Pro—a cutting-edge single-molecule protein sequencing technology on an accessible, benchtop instrument How this technology bridges the ...
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Proteomics Stage30 minsMass spectrometry-based proteomics methods are rapidly advancing with improved sensitivity, throughput and reliability supporting a wide range of clinical applications. Such advances are also enablin ...
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Proteomics Stage85 mins
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Proteomics Stage30 minsThis talk will cover the development of a proteomics-based aging clock using plasma protein data from over 50,000 UK Biobank participants. We’ll demonstrate how this data can be used to support risk ...
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Proteomics Stage30 minsSponsored by Olink
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Proteomics Stage30 minsProteogenomic quantification to create patient-specific tumor “atlas” Targetable dependencies of druggable genes From this talk you will learn about how proteogenomic methods are being used to support ...Speaker(s)
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Proteomics Stage30 mins
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Proteomics Stage30 minsStudying the proteogenomic landscape of TNBC appears to be a promising method to identify therapeutic vulnerabilities and new treatment options. We’ll discuss how how we used the Cancer Genome Atlas t ...
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Proteomics Stage30 minsTBC
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Proteomics Stage30 minsRecent advances in proteomic technologies, coupled with next generation sequencing, has enabled proteogenomic profiling of large cohorts, especially in cancer. Cloud-based platforms for proteogenom ...
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Proteomics Stage30 minsUsing high-throughput proteomic profiling to identify new exploratory biomarkers from blood samples. The new opportunities these biomarkers bring to drug discovery and development e.g. target engag ...
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Proteomics Stage30 minsTBC
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Proteomics Stage30 minsCommon animal models for atherosclerosis entail genetic manipulation of lipid metabolizing proteins. Proteome profiling of these models has been limited to primarily solid tissues such as diseased liv ...
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Proteomics Stage70 mins
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Proteomics Stage30 minsBuilding a computational workflow to probe and analyze multiomic datasets Spatial analysis methodologies customized for spatial proteomics and transcriptomics datasets, with a focus on techniques rela ...
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Proteomics Stage30 mins
Organ systems are composed of unique cell types that actively coordinate to enable higher order functions. Even slight deviances in the molecular or cellular states of these systems can result in debilitating disorders whose severity, treatment course, and overall treatment outcome vary widely from patient to patient.
This level of complexity likely contributes to promising therapeutics failing within clinical trials and, thus, require further exploration. Thus, the Neumann lab focuses on developing and applying multimodal imaging and profiling techniques to study the molecular and cellular architecture behind complex human diseases, such as renal cell carcinoma, Alzheimer’s Disease, and Canavan’s Disease.
To do this, we combine multiple analytical tools to detect molecules throughout the central dogma of biology, including genes, proteins, and metabolites.
Our main instrument is the Bruker timsTOF fleX MALDI MS system, which enables us to detect hundreds to thousands of metabolomic features at <10 µm spatial resolution.
In conjunction with immunohistochemistry and spatial transcriptomics, we can connect these metabolomic profiles to specific cell types and cell states. These integrated technologies can be used on a variety of biological samples with high reproducibility and rigor.
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Proteomics Stage30 minsIntegrated analysis of high-resolution, high-plex spatial transcriptomics and proteomics allows for improved annotation of immune cells Inference of correlated changes in cell-cell interactions drivin ...