This theatre will showcase how you can leverage the latest wet-lab single-cell and spatial techniques to get key insights into disease biology, how to overcome challenges in data integration and the utility of these techniques to discover novel drug targets. This theatre will complement the single-cell and spatial workshops happening at the Festival.
11:30
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Single-Cell and Spatial30 minsSingle cell atlases as a cellular road map Cross-disease analysis of single cell atlases reveals pathogenic cell states for early drug discovery Single cell atlases transformed our understanding of th ...
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12:00
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Single-Cell and Spatial30 minsAs single cell technologies have advanced, assay scalability has become a critical factor in capturing the full heterogeneity and complexity of biological systems. With the release of the Evercode WT ...
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12:30
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Single-Cell and Spatial30 minsSingle cell and spatial transcriptomics data are new types of data that offer in-depth knowledge on cellular heterogeneity of tissues We take advantage of such heterogeneity to design new generation o ...
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13:00
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Single-Cell and Spatial70 mins
14:10
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Single-Cell and Spatial30 minsSingle-Cell Sequencing to Evaluate ABBV-CLS-484: A first in class, first in mechanism PTPN1/2 inhibitor driving potent antitumor immunity
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14:40
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Single-Cell and Spatial30 minsIn this talk, Sam Cooper (CTO) will share how Phenomic has worked with Scale Bio to perform arrayed CRISPR–scRNA-seq screens in patient-derived co-cultures to identify causal cell-cell interactions in ...
15:10
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Single-Cell and Spatial30 minsCancer arises from the interplay of genetic and non-genetic factors, including cell identity, epigenetics, and the microenvironment. Understanding how mutations interact with non-genetic determinants ...
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15:40
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Single-Cell and Spatial30 mins
16:10
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Single-Cell and Spatial30 minsA hierarchical Bayesian model jointly models and aligns spatial transcriptomic, spatial proteomic, and single-cell sequencing data on matched tissues MultiTME learns unified transcriptional and proteo ...
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16:40
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Single-Cell and Spatial30 mins• Description of the Flexomics solution for collecting paired phenotypic/functional and transcriptomic data at single cell resolution • Example applications leveraging the Flexomics platform ...
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17:10
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Single-Cell and Spatial30 minsWe show that a wide spectrum of TP53 mutations can remodel the cancer intrinsic properties of lung adenocarcinoma in a consistent manner across primary tumors, cell lines, and genetically engineered m ...
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11:30
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Single-Cell and Spatial30 minsWe describe challenges with commonly used pileones and introduce a statistical method that accounts for mixed cell-type signals within each capture spot, a common issue in Visium and SlideSeq data, pe ...
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12:00
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Single-Cell and Spatial30 minsSpatial biology unlocks new insights into tissue and cell biology. Our AI-powered analysis allows integration of data across assays and technologies Users can explore multicellular environments, and ...
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12:30
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Single-Cell and Spatial30 minsHow does spatial molecular pathology provide insights into tissue architecture and patient heterogeneity, aiding in more precise drug development? How do single-cell spatial approaches uncover cell ph ...
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13:00
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Single-Cell and Spatial50 mins
13:50
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Single-Cell and Spatial30 minsProblem: Too many potential TME hypotheses for disease states to test. Most are “red herrings”. Pursuing them one at a time is risky. Opportunity: Factorization-based methods applied to scRNA-seq atl ...
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14:20
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Single-Cell and Spatial30 minsExplore how single-cell transcriptomic analysis reveals gene expression patterns in individual cells, uncovering insights into metastatic progression. Investigate how spatial transcriptomics allows ma ...
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14:50
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Single-Cell and Spatial30 mins
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