)
)
Alzheimer Pathology in Space and Time
-
Employ correlative chemical imaging and spatial transcriptomics to follow Alzheimer pathology in genetic APP mice
-
Use stable isotope encoded protein imaging to map protein turnover and dposition into pathological features (amyloid plaques) at the low micrometer resolution to guide correltaive ST to identify plaque age/protein aggregate age and structure associated changes in local cellular gene expression
-
Identify that early amyloid peptide aggregates affect synaptic genes and immune cells long before prominent plaque pathology is established
