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Decoding Human Variation at Single-Cell Resolution: Genetic Insights from the TenK10K Atlas
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Leverage the largest matched single-cell RNA-seq and whole-genome sequencing dataset of n~2,000 (TenK10K) to uncover genetic regulation across immune cell types.
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Identify common and rare variant effects on gene expression with a novel single-cell aware mapping method (SAIGE-QTL).
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Reveal cell type- and state-specific regulatory mechanisms with implications for complex trait and disease biology
