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An Exploration Into How Large-Scale Genomic Studies Are Helping Us Understand Disease at National and Global Levels
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The application of large-scale genomic analyses to multi-omic phenotypes to investigate the contribution of genetic variants associated with complex human traits.
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The value of genome sequencing and imputation to extend genomic analyses to low frequency and rare variants and locus fine-mapping.
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How these expansive, high-resolution atlases of multi-omics changes inform understanding of mechanisms of disease.
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Efforts to assess quantitatively the contribution of cis -genetic effects to transcriptional variance, to characterise coordination of genetic effects on gene expression, methylation and histone variation and characterise genetic and epigenetic influences at human disease lock and key immune pathways.
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How these results are helping us better understand genetic and molecular events underpinning cardiometabolic and immune function in humans.
