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Exploring Multiscale Single-Cell Signalling via SIGNAL-seq PTM Profiling and Biophysics-Aware Spatial Transcriptomics
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SIGNAL-seq captures RNA and post-translational protein modification states per cell, capturing both inter- and intra-cell communication with downstream gene expression.
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BISTR models cytokine diffusion from spatial transcriptomes, pinpointing ligand-driven gene programs in situ.
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Both technologies provide complementary views that can yield a causal map of tissue biology from secreted ligand to signalling and downstream gene programs.
