)
)
Precision Prediction and Prenatal Intervention for SCD: A Multimodal Biomarker Approach
- Why current prenatal diagnostics for monogenic disorders provide genotype but not phenotype, and how this limits early counselling and intervention planning.
- Path to prenatal translation, including opportunities for early in-utero monitoring, patient-specific counselling, and precision fetal-medicine interventions.
- Case example: a data-driven framework for stratifying disease severity in sickle cell disease using integrated clinical, laboratory and machine-learning approaches to develop future prenatal prediction tools.
- A multimodal biomarker strategy combining fetal genetics, maternal biomarkers, early placental signals, and clinical risk factors to improve prediction of postnatal disease trajectories.
