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Insights From Molecular Mapping of Gastrointestinal Cancer Across Space and Time
- Studying clinical cohorts using spatial transcriptomics technologies offers the potential to impact our understanding of patients tumours.
- Our central hypothesis is single-cell spatial characterisation will reveal therapeutic vulnerabilities not apparent when studying immune cell populations without spatial context.
- We aim to unravel the spatial interplay between cancer cells, and microenvironment as determinants of tumour progression across a variety of GI cancers including pancreatic and colorectal cancers.
- We have characterised large cohorts of human GI cancers using regional and single-cell transcriptomics strategies in the primary and metastatic setting in effort to better understand the impact of treatment and disease progression.
