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Multiomic Single Cell WGS and Epigenomics to Track Drug Resistance Evolution in Cancer
- Introduction of our “dATAC” method for single cell combined whole genome sequencing and ATACseq
- Application of dATAC to study colorectal cancer evolution in model systems and patients
- The evolution of chemotherapy resistance involves selection jointly on genetic mutations and epigenome configuration
- Metastatic dissemination is clonally complex and involves ongoing epigenetic alteration
