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RNA Methylation and dsRNA-Mediated Immunogenicity as Biomarkers for Predicting Cancer Cell Sensitivity to Treatment
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Despite expressing immunostimulatory retroelement (RE) transcripts, many cancer cells evade immune detection
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RE transcripts can form double-stranded RNAs (dsRNAs), mimicking viral infection and triggering innate immune responses
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Cancer cells suppress this immunogenic signal through RNA-level checkpoints, limiting the effectiveness of viral mimicry
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Colorectal cancer tumours show variable responses to RNA methylation inhibition
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Combining RNA and DNA methylation inhibitors may overcome immune resistance in CRC tumours
