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Safe by Design: Unbiased Tools for CRISPR Safety in Cell and Gene Therapy
- Unbiased, PCR-free strategies for genome-wide CRISPR safety assessment
- Chromosomal stability as a key metric for off- and on-target evaluation
- Optical genome mapping versus conventional PCR approaches
- Novel image-based methods for Cas9 off-target detection
- Implications for designing safer cell and gene therapies
