Professor Kilby has practiced Fetal Medicine and therapy in the United Kingdom for 28 years.In the last 15 years, one of his ‘pillars’ of research was investigating the application and clinical utility of new genomic technologies in prenatal diagnosis. Initially, he was involved in the clinical application of Chromosome Microarray platforms in investigating the fetal with congenital malformations. He was a Principal investigator on the Wellcome Trust-funded Prenatal Assessment of Genomes and Exomes (PAGE) study which involved the feasibility, diagnostic accuracy and utility, patient acceptability, and health economics of the prenatal application of exome sequencing in the fetal with congenital malformations. He was Chair of the Royal College of Obstetricians and Gynaecologists (RCOG) Genomic Taskforce (2019-2024) and is a member of the Joint Colleges Committee of Genomic Medicine, and a member of the Genomics England, Newborn Screening group for a ‘pilot study’ investigating the use of whole Genomic sequencing. He is also the RCOG Representative at the Joint Colleges Committee on Genomic Medicine. For two years, he was a Senior Principal Clinical Scientist at the Medical Genomics Research Group at Illumina, Cambridge, UK (2022-2024). He continues to work as a clinician in the Joint Fetal Medicine /Genetics Clinic, in Birmingham, UK. He was Clinical Lead in Fetal Medicine and Therapy at the Birmingham and West Midlands Fetal Medicine Centre, at Birmingham Women’s & Children’s Foundation Trust from 1995 – 2022, and Dame Hilda Lloyd Chair of Fetal Medicine for the same period.