Speakers

Consultant Nephrologist, Oxford Kidney and Transplant Unit 

Career Development Fellow, CAMS Oxford Institute, Nuffield Department of Medicine 

Academic Lead, CAMS Oxford Spatial & Gene Profiling Hub 

Dr Bottomley is clinician-scientist at the Chinese Academy of Medical Sciences Oxford Institute (COI) and a practicing consultant nephrologist at the Oxford Kidney and Transplant Unit, Churchill Hospital.  

His research focus is on the impact of post-transplant pharmacological immunosuppression upon circulating and peripheral immune responses against viruses and malignancy. He and his group work at the translational boundary, identifying novel clinical and immunological parameters to aid risk stratification in this high-risk cohort, as well as developing novel therapeutic approaches to mitigate the burden of disease. They utilise multimodal approaches including (spatial) proteotranscriptomic profiling and functional validation.  

He has published several papers regarding the use of circulating immunological parameters to identify kidney transplant recipients at highest risk of subsequent malignancy development (Bottomley et al, J Am Soc Nephrol 2015; Bottomley et al, Front Immunol, 2022; Ahuja et al, Nat Comms, 2023) and is the principal investigator for two multicentre studies evaluating the optimal management of skin cancer after transplant (Whitley, Wang et al, Transplantation Direct, in press). He is a board member for the British Society of Skin Care in Immunocompromised Individuals (BSSCII). 

He is also the academic lead of the COI Gene and Spatial Profiling Hub, which has a proven track record of collaboration with academic and commercial partners across the UK and internationally to deliver high-quality spatial profiling outputs across multiple species and tissue types.