Speakers

Dr. Alexi Nott’s research focuses on determining how the epigenome and chromatin architecture regulate gene expression programs specific to different cell types in the brain, both under healthy conditions and during ageing and disease. Alexi joined Imperial College London in 2020 as a Lecturer in the Department of Brain Sciences and a Group Leader in the UK Dementia Research Institute. Alexi received an Alzheimer’s Association Research Fellowship and a KL2 Mentored Career Development Award at the University of California, San Diego. During this period, he generated cell-type-specific epigenetic atlases of the human brain and discovered that many genetic risk variants for Alzheimer’s disease are concentrated in active gene regulatory elements within microglia. Alexi's group utilises nuclei isolation methods and genome-wide sequencing approaches to profile the epigenome of brain cell types using patient-derived archived tissue. Using these approaches, Alexi’s research examines the epigenome of the human brain to understand how genetic variation contributes to age-related brain disorders.