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Sankari Nagarajan

Sankari Nagarajan

Lecturer in Chromatin Biology, University of Manchester

I am a breast cancer research scientist investigating the transcriptional regulation of disease progression in breast cancers. After obtaining a prestigious and competitive PhD scholarship from German Academic Exchange Service (DAAD), I moved to the University of Goettingen, Germany. My successful PhD research on an epigenetic reader protein BRD4 in ER+ breast cancers introduced the possibility of using Bromodomain and Extraterminal domain-containing protein (BET) inhibitors as a therapeutic strategy against breast cancers. This body of work resulted in me being awarded best PhD. 

As a Research Associate, I worked with Prof. Jason Carroll, CRUK Cambridge Institute. Using genome-wide CRISPR-based drug resistance screens and functional genomic approaches (ChIP-seq, ATAC-seq, RNA-seq), I investigated a novel role for the SWI/SNF chromatin remodelling complex, and its subunit ARID1A in controlling endocrine treatment response. Then, I moved to Manchester to start my first PI position in the Division of Molecular and Cellular Function. I was awarded a CRUK Career Establishment award and CRUK Biology to Prevention award. I serve as a member of the scientific committee of the Lobular Breast Cancer UK charity. I strongly support patient engagement activities and mentor early-career students/postdocs to advance women in academia and science who have childcare responsibilities.   

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