29th - 30th January 2025 | ExCeL, London
DATA-DRIVEN DRUG DISCOVERY STAGE
Harnessing Big Data to Accelerate Breakthroughs in Drug Discovery & Development
The Data Driven Drug Discovery Stage covers integrating multi-omics data, using AI for multi-modal data analysis and making actionable drug discovery decisions whilst addressing privacy and FAIR data standards.
DAY 1
On Day 1, The Data Driven Drug Discovery Stage will focus on Omics in Drug Discovery, Multi-Omics in Drug Discovery and Data Driven Drug Discovery.
[topic] OMICS IN DRUG DISCOVERY
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Using Genomics to Infer Networks of Causal Genes and Choose New Drug Targets
- Industrializing use of large scale GWAS and WGS/WES to identify genes causal for disease.
- Using gene editing at genome-scale to infer cell- and condition-specific causal networks.
- Applying mechanism and pathway insights to prioritize drug targets.
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Uncovering New Evidence to Inform and Validate Drug Discovery Decisions
Sponsored by
- By incorporating cause-and-effect data into knowledge graphs, researchers can access unique insights that arise when data is aggregated in this manner
- Dr Daniel Jamieson will demonstrate the power of advanced cause and-effect capturing methods, coupled with generative AI (genAI), in facilitating groundbreaking conclusions for drug discovery
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When combined together, these technologies allow for more efficient and targeted experimentation, accelerating the development of novel treatments and therapies.
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Accelerating Drug Discovery Through the Power of Genomics, Machine Learning and Medical Big Data
- Data and analytics are key for learning and improvement as we translate research insights for patients
- We increase translational probability of success through:
- (1) Mapping causal human biology through genomics across disease spaces
- (2) Understanding longitudinal patient journeys Innovation opportunities through multi-disciplinary teamwork between in silico / therapeutic areas
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[break] Lunch
- Exhibition Floor : Wander around the vibrant exhibition floor to see the latest technologies and services on offer
- Food Options : Grab a sandwich at The Tree of Life Cafe or head on over to the Food Village for a range of hot food options including Indian, Jamaican and Japanese food
- Live Lounge Over Lunch : 15 mins technology focussed presentations
- Poster Zone : Browse the posters and reach out to potential new collaborators
- Talkaoke : The Flying Saucer of Chat, a fun and interactive pop-up show that offers you the opportunity to sit down with others and discuss any topic you like.
- Patient Perspectives: Talks and discussions on the crucial role of patients and patient families in the understanding and development of treatments for rare diseases.
[topic] MULTI-OMICS IN DRUG DISCOVERY
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The Expanding Role of Multi-omics in Early Drug Discovery
- How multi omics is supporting early drug development and supporting the successful uptake of therapies.
- Using multi-omics to identify new disease biomarkers.
- How can we integrate and bring multi modal data together.
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What are the current challenges and future directions.
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Sponsored Talk Available
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Leveraging Multi-modal Big Data in Drug Discovery and Development
- Using the latest single cell proteomics methods to understand virus replication biology.
- Developing new methods to improve sensitivity, depth and coverage of single-cell proteomics methods.
- Applications to different model systems and improving analysis.
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[break] Break
- Speed Networking: Fun and useful sessions where you’ll rapidly meet other Festival attendees to immediately expand your network.
- Food Options : Grab a coffee and a cake at The Tree of Life Cafe or head on over to the Food Village for a range of hot food options including Indian, Jamaican and Thai food
- Exhibition Floor : Wander around the vibrant exhibition floor to see the latest technologies and services on offer
- Talkaoke : The Flying Saucer of Chat, a fun and interactive pop-up show that offers you the opportunity to sit down with others and discuss any topic you like.
[topic] DATA-DRIVEN DRUG DISCOVERY
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Knowledge Graphs for Precision Oncology
- Knowledge Graphs have in recent years gained a lot of prominence within biomedical AI applications, driven by the need for study-specific knowledge to be integrated with the world’s knowledge to obtain a deep and comprehensive view of complex disease landscapes such as in Oncology.
- This presentation will discuss the applications of Knowledge Graphs across the drug discovery pipeline – from target discovery, combination prioritisation, patient stratification and clinical biomarker discovery.
- The talk will also cover how KGs can help bridge the critical bench-to-bedside gap in biomedical R&D by translating Discovery knowledge to Clinical applications, including current limitations of the field.
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Multi-omics Data Analysis for Identifying, Prioritising & Validating Novel Drug Targets
- STORM Therapeutics is a clinical stage biotechnology company creating novel therapies targeting RNA modifying enzymes for use in oncology and other diseases
- As a small biotech company working in a novel field of biology, the use of bioinformatics and multi-omics is essential at every stage of the drug discovery pipeline
- We use multi-omics during identification and validation of novel drug targets, to elucidate target/drug MoA and identify disease positioning strategies
- We are developing bespoke RNA omics readouts and computational workflows in-house as part of our proprietary RNA analytics platform"
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Using Big Omics Data to Advance the Discovery of Genetic Medicines
- The latest approaches to support the discovery of oligonucleotide therapeutics.
- New approaches to target ID Using cell specific disease expression data and linking to meaningful clinical phenotypes.
- Bioinformatic challenges associated with generating and accessing this data
DAY 2
On Day 2 the focus on The Data-Driven Drug Discovery Stage will be on AI in Drug Discovery and Data Management in Pharma. The track will end with a panel discussion on AI in drug discovery from Discovery to Clinical Application.
[topic] AI IN DRUG DISCOVERY
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Artificial Intelligence and Machine Learning Across the Entire Drug Development Pipeline
- It is well known that AI/ML have the potential for acceleration and innovation within pharmaceutical research and development
- However, it is less widely known that the potential impacts span the entire drug development pipeline, from target identification, through molecule design and optimisation, clinical trials, and all the way to commercial investment decisions
- This talk will describe how different ML/AI is being used right now across different parts of the pipeline, with examples such as the design of molecules, biological insight generation, novel biomarkers, and clinical trial optimisation
- The talk will conclude by giving an indication of the future outlook, along with some open challenges that are faced by the industry
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Sponsored Talk Available
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Innovations in Clinical Development: Harnessing Synthetic Data Generation and Multi-Modal Integration with AI
- Introduction to Synthetic Data Generation: Exploring the role of generative models in creating synthetic datasets for clinical research, facilitating data augmentation, and addressing challenges of limited sample sizes.
- Case Studies in Deep Learning: Highlighting successful applications of deep learning in analyzing multi-modal clinical data, including genomic sequencing, medical imaging, and electronic health records, to uncover novel insights and accelerate drug discovery.
- Ensuring Data Privacy with Differential Privacy: Discussing the implementation of differential privacy techniques to protect patient confidentiality while enabling the sharing and analysis of sensitive clinical data across research institutions.
- Advancements in Multi-Modal Integration: Demonstrating the importance of integrating diverse data sources, such as patient demographics, genetic profiles, and real-world evidence, to enhance the efficacy of AI-driven models in predicting treatment outcomes and optimizing clinical trial designs.
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[break] Lunch
- Exhibition Floor : Wander around the vibrant exhibition floor to see the latest technologies and services on offer
- Food Options : Grab a sandwich at The Tree of Life Cafe or head on over to the Food Village for a range of hot food options including Indian, Jamaican and Japanese food
- Live Lounge Over Lunch : 15 mins technology focussed presentations
- Poster Zone : Browse the posters and reach out to potential new collaborators
- Talkaoke : The Flying Saucer of Chat, a fun and interactive pop-up show that offers you the opportunity to sit down with others and discuss any topic you like.
[topic] DATA MANAGEMENT IN PHARMA
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Fusion Between Data Mesh, FAIR & Data Governance
- Data Mesh decentralizes data ownership, making each domain responsible for its own data as a product, fostering more agile and scalable data management.
- Integrating FAIR principles ensures that data in a Data Mesh is Findable, Accessible, Interoperable, and Reusable, enabling easier data discovery, collaboration, and integration across domains.
- Effective data governance in a Data Mesh framework maintains standards for data quality, privacy, and security, ensuring compliance while supporting innovation and trust in decentralized environments.
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Pragmatically FAIR – Providing Just Enough Structure to Drive Discovery and Value
- Goldilocks and the three data governance drivers
- Modelling, Ontologies and Reference data
- Getting it right – when to use ontologies
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Getting it right – modelling to the nth degree
Speaker
Senior Product Owner, Reference Data, Information & Data Architecture and Ontologies
GSK
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Enabling Innovation with FAIR OMICS Data Management: A Boehringer Ingelheim Perspective
- FAIR OMICS Data Management yeilds measurable return on investment.
- FAIR Infrastructure is essential for promoting user-adoption and generating data-driven value.
- Governance assumes a central role in the integration of data management processes within the organization.
Speakers
IT Lead Business Consultant and Capability Lead for Global Omics Data Management and CompBio Data Service
Boehringer Ingelheim
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[break] Break
- Speed Networking : Fun and useful sessions where you’ll rapidly meet other Festival attendees to immediately expand your network.
- Food Options : Grab a coffee and a cake at The Tree of Life Cafe or head on over to the Food Village for a range of hot food options including Indian, Jamaican and Thai food
- Exhibition Floor : Wander around the vibrant exhibition floor to see the latest technologies and services on offer
- Talkaoke : The Flying Saucer of Chat, a fun and interactive pop-up show that offers you the opportunity to sit down with others and discuss any topic you like.
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PANEL: AI in Drug Discovery: The Journey from Discovery to Clinical Application
- How can AI support drug target ID and early drug discovery (e.g. molecule design and optimisation). Applying AI in precision medicine approaches.
- How can AI be used in the later stages of clinical development (e.g. improving/optimising clinical trials).
- What are the challenges associated with using AI such as integrating huge data sets, access to high quality data and how can we demonstrate these tools are robust and reliable.
- What are the other privacy concerns associated with using AI to process sensitive genomic and clinical data sets?
Speakers