LIVE LOUNGE

Ethics and Interactions With The Environment - Bridging the Gap for Genomics for all

The Live Lounge addresses epigenetics in mental health, equitable access and diversity in genomic studies, and challenges in women’s health, prenatal care and newborn screening.

DAY 1


 The Live Lounge will begin by focusing on Genomics in Psychiatry and Mental Health. It will end day 1 looking at ethics, diversity and patient perspectives. Day 2 will focus on women's health, ante-natal testing and newborn screening.

[topic] GENOMICS INTERACTING WITH THE ENVIRONMENT
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DATAMIND – The UK Mental Data Hub
  • This talk will present DATAMIND which is a health data research hub for mental health.
  • We’ll discuss the core activities of this research hub including the FAIR curation of mental health data.
  • We’ll show how the DATAMIND hub is cataloguing and curating UK mental health data rich datasets which are within the fields of genomics, routine care, trials for research, the NHS, academia, industry and so on.
  • Finally we’ll cover how patient and public engagement is a core aspect of the project.
Speaker
Professor of Public Health and Psychiatry, Health Data Science
Swansea University
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A Multiomics Approach to Understanding the Regulation of Sleep And Circadian Rhythms
  • Sleep is fundamental to our health, and its disruption, as seen widely in today’s 24/7 society can precipitate multiple long and short-term diseases.
  • Despite its importance, the molecular underpinnings of sleep remain largely enigmatic.
  • My lab works on the gene regulatory landscape that controls the timing of sleep and circadian rhythms.
  • Here I will present our latest findings on how chromatin accessibility changes in key brain regions changes across the day and in response to sleep deprivation, and its consequences on brain function and health. 
Speaker
Associate Professor
University of Oxford
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Food, Epigenetics, Metabolic Responses and Health
  • How diet influences epigenetic regulation of gene function, and its impacts on subsequent cardio-metabolic health outcomes
  • Overview of the DIMENSION Consortium
  • The intersection between epigenetic and functional genetic changes after food intake, and the potential of personalised nutrition
Speaker
Reader in Epigenomics
King's College London
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Live Lounge Over Lunch Presentation 1

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Live Lounge Over Lunch Presentation 2

Sponsored by:


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Live Lounge Over Lunch Presentation 3

Sponsored by:


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Live Lounge Over Lunch Presentation 4

Sponsored by: 


[topic] GENOMICS IN PSYCHIATRY & MENTAL HEALTH
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The Genetics of Treatment Resistant Depression in The Pakistani DIVERGE Study
  • There is an immense lack of diversity in genetic research.
  • Very few studies are carried out in low- and middle income countries In one of the largest dedicated studies of depression genetics, we are recruiting 9,000 patients from across Pakistan
  • I will present the first genetic findings from this novel, deeply phenotyped cohort
  • We investigated the genetic risk factors for developing treatment resistant depression which is responsible for the majority of the burden of this disorder
Speaker
Professor of Genetic Epidemiology
University College London
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Epigenetic Embedding of Prenatal Stress in Humans
  • Importance of prenatal/perinatal tissue (placenta, cordblood)
  • Definitions of prenatal stress
  • Overview of findings from prenatal studies and our own findings
  • Directions for future studies 
Speaker
Team Leader
Max Planck Institute of Psychiatry
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Epigenetic Regulation By Stress
  • Epigenetic regulation by stress during prenatal, postnatal and adulthood.
  • Animal models and human studies to study epigenetic mechanisms.
  • Epigenetic regulation by influenced by genetics.
Speaker
Professor of Epigenetics
Manchester Metropolitan University
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[break] Break
  • Speed Networking: Fun and useful sessions where you’ll rapidly meet other Festival attendees to immediately expand your network.
  • Food Options : Grab a coffee and a cake at The Tree of Life Cafe or head on over to the Food Village for a range of hot food options including Indian, Jamaican and Thai food
  • Exhibition Floor : Wander around the vibrant exhibition floor to see the latest technologies and services on offer
  • Talkaoke : The Flying Saucer of Chat, a fun and interactive pop-up show that offers you the opportunity to sit down with others and discuss any topic you like.
[topic] ETHICS, DIVERSITY & PATIENT PERSPECTIVES
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Improving Black Health Outcomes
  • First dedicated research resource in this country to help us understand how health conditions can specifically affect people from Black communities
  • King’s College London in partnership with NIHR BioResource and Genomics England building research cohort up to 10,000 Black participants
  • How Black community PPI contributed to every step in IBHO design and delivery
Speaker
Reader in Clinical Psychology
King's College London
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Putting People First: Designing Ethical and Inclusive Engagement in Genomics
  • Overview of how Genomics England are ensuring equity
  • The potential of large scale datasets
Speakers
Director of External Affairs
Genomics England
Head of Digital Communications, Content and Brand
Genomics England
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D-CYPHR: Working With Families to Create a World First Children’s Genetic Health Research Programme
  • The DNA, Children + Young People’s Health Resource is led by the NIHR BioResource in partnership with the NHS, and created with children, young people and parents from inception
  • Most diseases start in childhood but most research is carried out with adult participants. What is the role of genetic research involving children and young people in overcoming child and adult health problems, and reducing burden on healthcare system
  • How does digital recruitment overcome traditional barriers to research participation in underrepresented populations, both children and minority ethnic communities, and work to address health inequalities they face D-CYPHR facilitates research into a wide range of physical and mental health areas, allowing access to data, samples and recall of consented volunteers by genotype and/or phenotype
Speaker
Operations Lead
NIHR BioResource

DAY 2

Day 2 on the Live Lounge Stage focuses on women's health, ante-natal testing and newborn screening.

[topic] WOMEN'S HEALTH
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Personalising Endometrial Cancer Follow-Up
  • ctDNA to risk-stratify endometrial cancer follow-up
  • Impact of endometrial cancer follow-up on patients, clinicians and the healthcare economy
  • Supporting patients’ survivorship journeys: the need for equity
Speaker
Associate Professor in Gynaecological Oncology, Leicester Cancer Research Centre
University of Leicester
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Global Women’s Health Initiatives to Investigate Novel Approaches to Improve Health Care Delivery
  • Preventing cardiometabolic complications in women after high-risk pregnancy conditions such as gestational diabetes and preeclampsia using technology and AI
  • SMART Health Pregnancy trial in India: This trial is being conducted in two rural districts in two states, and is evaluating a community-based intervention and digital clinical decision support tool to improve screening, management and referral of high risk conditions during pregnancy and in the in first year after birth
Speaker
Director of Women’s Health
The George Institute for Global Health at Imperial College London
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Understanding the Long-Term Impact of Chemotherapy during Pregnancy: Exploring Third Generation Effects
  • Cancer is diagnosed in around 1 in every 1000 pregnancies, estimated to lead to treatment of 3,000-5,000 pregnant patients each year in Europe.
  • Chemotherapy drugs can cross the placenta, but are considered safe to administer after the first trimester.
  • Surprisingly, follow-up studies on children exposed in utero do not include examining effects on fertility, despite the well-known effects of chemotherapies on fertility.
  • My research aims to shed light on whether and how these drugs can affect the developing gonads.
  • Results could inform clinicians and help elucidate if the children born to pregnant women treated with chemotherapy should in due course be assessed for fertility preservation
Speaker
Teaching Track Lecturer in Reproductive Biology
University of Edinburgh
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LIVE LOUNGE OVER LUNCH PRESENTATION 1

Sponsorship Available

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LIVE LOUNGE OVER LUNCH PRESENTATION 2

Sponsorship Available

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LIVE LOUNGE OVER LUNCH PRESENTATION 3

Sponsorship Available

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LIVE LOUNGE OVER LUNCH PRESENTATION 4

Sponsorship Available

[topic] GENOMICS IN PREGNANCY AND PRENATAL SEQUENCING
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Causes & Consequences of Intrahepatic Cholestasis of Pregnancy
  • Metabolomics and metagenomics impact on cholestasis
  • Risk of still birth and management
  • Cholestasis of pregnancy association with an increased incidence of adverse perinatal outcomes and risk for gestational diabetes
Speaker
Clinical Senior Lecturer
King's College London
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Enhancement of Fetal Phenotyping in Investigation of Fetus Using Next-Generation Sequencing
  • Congenital malformations complicate up to 5% of all pregnancies and have increased perinatal mortality and morbidity. Up to 25% of structural anomalies detected by ultrasound are associated with chromosomal aneuploidy and copy number variants (CNVs).
  • However, even when these are excluded there is an overall associated long-term morbidity. Internationally, prenatal genomic sequencing, focusing on the exome (ES), is now commonly offered. The pre-test selection of fetuses and identifying a fetal phenotype by a multidisciplinary team of experts is key to increasing the diagnostic yield of such testing, which may be between 30-50%
  • However, many dysmorphic features are subtle and require expert ultrasonographic visualization, additional diagnostic imaging (i.e. MRI), and AI technologies to optimize fetal selection for such testing.Presently in many healthcare systems prenatal genomic testing is guided by the recognition of a ‘fetal phenotype’ that is at high risk of associated underlying genetic etiology. But is this selection process changing internationally? "
Speaker
Emeritus Professor of Fetal Medicine
University of Birmingham
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Fetal Phenotyping: The Importance of Recognizing Anomalies to Maximize Diagnostic Accuracy of Prenatal Genomic Sequencing
  • Antenatal DNA screening has advantages over other screening methods.
  • High screening performance – very low false positive rate and detection rate.
  • No uninformative screening results.
  • Low cost.
  • Preserves AFP screening for neural tube defects.
  • Preserves screening for pre-eclampsia. "
Speaker
Professor of Preventive Medicine
UCL Institute of Health Informatics
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[break] Break
  • Speed Networking : Fun and useful sessions where you’ll rapidly meet other Festival attendees to immediately expand your network.
  • Food Options : Grab a coffee and a cake at The Tree of Life Cafe or head on over to the Food Village for a range of hot food options including Indian, Jamaican and Thai food
  • Exhibition Floor : Wander around the vibrant exhibition floor to see the latest technologies and services on offer
  • Talkaoke : The Flying Saucer of Chat, a fun and interactive pop-up show that offers you the opportunity to sit down with others and discuss any topic you like.
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Identifying Newborn Patients with Inborn Errors of Metabolism
  • New diagnostic platforms that enable better diagnosis, better understanding treatment and better treatment
  • Digital microfluidics to improve diagnosis of newborns with lysosomal disorders Identifying variants of unknown significance functionality
Speaker
Professor, Consultant Clinical Scientist
Great Ormond Street Institute of Child Health
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The Generation Study – Newborn Screening through Whole-Genome Sequencing
  • Updates on The Generation Study
  • How the study is supporting the identification of rare conditions in babies earlier
  • How the study is exploring the risks and benefits of storying an individual's genome over their lifetime
  • Early findings 
Speaker
Programme Lead - Newborns
Genomics England