BIODATA STAGE

Harnessing the power of high performance computing and storage solutions to overcome the challenges of big data analysis, sharing and access

The Biodata Stage will delve into the ethical and legal aspects of data sharing, maximising health data usage and infrastructure for large datasets, with talks on federated data and real-world evidence applications. 

DAY 1

The Biodata Stage focusses on big data storage and analysis, data storage, access and analysis in the cloud and big data supporting research.

[topic] BIG DATA STORAGE & ACCESS
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Advancing Genomics & Health Through Data
  • Overview of Elixir Europe’s big data projects and WHO Genomics Activities
  • How large-scale genomics programmes can support personalised health and research
  • Advances in the security and sharing of omics data across borders, including the GDI
Speaker
Director
ELIXIR
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Enhancing the Nextflow Experience: Boosting Efficiency, Scalability, and Best Practices for Bioinformatics Workflows
  • Enhanced Developer Experience: New tools and integrations with Nextflow streamline workflow creation, management, and deployment across various computational infrastructures
  • Introducing Seqera AI: A chat-based assistant that helps users generate functional workflow code from case descriptions, troubleshoot issues, and apply best practices, accelerating setup and development
  • Accessibility for All Users: Nextflow and Seqera AI make advanced workflow orchestration accessible to both new and experienced users, maintaining flexibility and power
  • Practical Takeaways: Attendees will gain insights and strategies for efficient workflow creation to maximize the impact of bioinformatics research
Speaker
Lead Developer Advocate at Seqera
Seqera

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Updates To The UK Biobank
  • Overview of updates to the UKBB
  • Infrastructure updates and the proteomics project
  • Imaging study updates and data releases
Speaker
Deputy CEO
UK Biobank
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[break] Lunch
  • Exhibition Floor: Wander around the vibrant exhibition floor to see the latest technologies and services on offer
  • Food Options: Grab a sandwich at The Tree of Life Cafe or head on over to the Food Village for a range of hot food options, including Indian, Jamaican and Lebanese food
  • Live Lounge Over Lunch: 15-minute technology-focused presentations
  • Poster Zone: Browse the posters and reach out to potential new collaborators
  • Talkaoke: The Flying Saucer of Chat, a fun and interactive pop-up show that offers you the opportunity to sit down with others and discuss any topic you like
[topic] DATA STORAGE, ACCESS, & ANALYSIS IN THE CLOUD
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Delivering a Federated Network of TREs to Enable Safe Data Analytics
  • How delivering a federated network of TRE's will enable researchers to perform better analysis across multiple TRE's
  • How streamlining how the processing is done by using adaptable, reproducible pipelines and computational workflows can support researchers
  • Next steps, and future directions for safe, accessible data sharing and analysis
Speaker
Professor of Digital Engineering and Health Informatics
University of Nottingham
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Optimizing Your Bioinformatics Workflow: Achieving a 64% Performance Boost and 63% Cost Savings—A Real Case Study from the Drug Discovery Process
  • Transforming bioinformatics pipelines for maximum efficiency requires more than minor code adjustments — it demands a complete verification of each bottleneck of the workflow. With data volumes and costs climbing, Ardigen on behalf of Quotient took an innovative approach to optimize Whole Genome Sequencing (WGS) and Whole Exome Sequencing (WES) processes within their existing Nextflow pipeline in the cloud. By integrating best practices from software engineering, DevOps, and bioinformatics, we achieved a 64% reduction in processing time and a 63% reduction in costs.
  • In this session, we’ll unpack the strategies behind these improvements and detail how we validated our approach to ensure reliability and scalability. We will also demonstrate how rethinking your approach to sequencing workflows can accelerate drug discovery. Join us to explore what's truly possible when you push the boundaries of pipeline optimization.
Speakers
Lead Nextflow Developer
Ardigen
Senior Bioinformatic Engineer,
Quotient Therapeutics

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Translational Research Opportunities in Our Future Health
  • An update on Our Future Health recruitment and data availability
  • Biospecimen access for biomarker discovery and validation
  • Recontact study possibilities including targeted trial recruitment
Speaker
Executive Director of Science
Our Future Health
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[break] Break
  • Speed Networking: Fun and useful sessions where you’ll rapidly meet other Festival attendees to immediately expand your network
  • Food Options: Grab a coffee and a cake at The Tree of Life Cafe or head on over to the Food Village for a range of hot food options, including Indian, Jamaican and Lebanese food
  • Exhibition Floor: Wander around the vibrant exhibition floor to see the latest technologies and services on offer
  • Talkaoke: The Flying Saucer of Chat, a fun and interactive pop-up show that offers you the opportunity to sit down with others and discuss any topic you like
[topic] BIG DATA SUPPORTING RESEARCH
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The Life of Data in The Crick
  • The heterogeneous research data landscape within the Crick
  • Data management lifecycle
  • Plans for data in the future and other considerations 
Speaker
Chief Data Officer & Head of Data Management & Analytics Platform Team
The Francis Crick Institute
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Revolutionizing Global Healthcare and Research: AWS’s Comprehensive Approach to Multi-Omics and Multi-Modal Analysis
  • AWS offers a comprehensive suite of specialized healthcare services, including HealthOmics, HealthImaging, and HealthLake, designed to revolutionize multi-omics and multi-modal research on a global scale
  • Through Amazon Bedrock, AWS is pioneering the application of Generative AI in healthcare and research, accelerating discoveries in areas such as protein structure prediction, drug development, and personalized medicine
  • Real-world case studies demonstrate how leading institutions worldwide are leveraging AWS to drive groundbreaking innovations in multi-omics research and precision medicine initiatives
  • AWS's global infrastructure ensures unparalleled data security, compliance, and scalability, enabling researchers and healthcare providers to confidently manage and analyze sensitive multi-modal datasets in the cloud
Speaker
Global Genomics and Precision Medicine Lead
Amazon Web Services

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Delivering Precision Health Through Globally Connected and Cloud Based Genomics Solutions
  • We have developed sBeacon (Nature Biotech, 2023), technology which enables consortia to share ‘omics data across globally connected networks and GeneGuardian, a privacy-preserving solution which enables dynamic consent for genomic data
  • I will outline our suite of tools capable of analysing population-scale genomic cohorts. Our technology leverages machine learning (ML) and cloud computing to achieve scalability and accessibility
  • Demonstrating impact, our tools VariantSpark and BitEpi utilize non-linear approaches to identify novel epistatic Alzheimer’s and Cardiovascular disease (CVD) genes in UK Biobank and validation cohorts (TopMed, ADNI)
  • We have fine mapped our results for CVD, utilising ML approaches with the UK Biobank WGS data, innovating on top of their cloud-based research analysis platform (RAP) to halve standard compute time and cost
Speaker
Team Lead- Genome Insights
CSIRO, Sydney, Australia

DAY 2

The Biodata Stage will be focussing on biodata and analysis as well as infrastructure optimisation. The day ends with a panel discussion on sharing data safely and efficiently.

[topic] SCALING BIODATA & ANALYSIS
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ELIXIR Supported Infrastructure to Enable Secure Access to Genomic Data
  • ELIXIR is supporting Europe to deploy infrastructure to facilitate the discoverability, access, sharing and analysis of genomics data linked to other data types, at scale (4-5M participants)
  • The talk will also discuss the impact of infrastructure in translating genomics research into medicine
Speaker
Head of Human Genomics and Translational Data
ELIXIR Europe
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Panel: Catalyst for Change: Cloud Innovation and Diversity Two Years On

Join industry leaders from Genomics England, UK Biobank, and the Francis Crick Institute for an engaging discussion on how cloud technology is driving innovation in the UK research sector.

In this session, they will discuss:

  • Progress towards UK's goal of becoming a science and technology superpower by 2030
  • The role of cloud computing in supporting the UK's scientific ambitions
  • Advancements in cloud technology and its impact on scientific research and collaboration
  • Developments in diversity and equity within the scientific sector
Speakers
Chief Data Officer & Head of Data Management & Analytics Platform Team
The Francis Crick Institute
Chief Scientist
UK Biobank
Chief Digital and Strategy Officer
Genomics England
Head of Healthcare UK
Amazon Web Services

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Opportunities in Health Research Powered by All of Us
  • This talk will present the latest updates from The All of Us Research Programme. This will include how the platform is effectively storing and allowing access to multi-modal data from electronic health records, surveys, physical measures, wearables data, and whole genome sequences.
  • We'll cover the main aims and priorities of The All of Us Programme to date, and how it can inform precision medicine approaches. Finally, we'll cover the main challenges that are currently faced and future directions.
Speaker
All of Us Researcher and Participant
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[topic] BIODATA SHOWCASE
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Empowering Genomics and Biodata Innovation with Advanced AI Infrastructure
  • Accelerating Genomics with AI Infrastructure: Explore how cutting-edge GPU-powered solutions from Nebius AI enable faster, more efficient workflows for genomics and biodata research, empowering breakthroughs in drug discovery and personalised medicine.
  • Tailored Solutions for Life Sciences: Learn how Nebius AI’s scalable, cost-effective platform addresses the unique computational demands of molecular modelling, iterative AI workflows, and synthetic biology applications.
  • Collaborative Innovation in Genomics: Discover opportunities to partner with Nebius AI to overcome computational bottlenecks, navigate the complexities of AI-driven research, and unlock new possibilities in life sciences.
  • Real-World Impact: Hear about real-world use cases showcasing how advanced AI infrastructure drives innovation in drug discovery, genome editing, and clinical research.
Speaker
Global LifeSciences & Healthcare Lead, Senior Business Development Manager
Nebius AI
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Transforming Drug Discovery with AI and High-Performance Computing
  • Recent advancements in GPU technology and LLMs revolutionized drug discovery and paved the way for the development of advanced in-silico techniques for analyzing biological sequences. These computational techniques have enabled researchers to virtually generate and evaluate a broad spectrum of hypotheses, thereby reducing the need for extensive wet-lab experiments in the early stages.
  • In this talk, we will explore how Quantiphi leverages a combination of its proprietary technology, GPU-accelerated models, and NVIDIA frameworks, along with optimised infrastructure, to accelerate the drug discovery pipeline. We will focus on Quantiphi's modified protein structure prediction pipeline, which samples multiple protein conformations and integrates deep learning with physics-based simulations to characterise ligand-protein binding affinities effectively.
Speakers
Head of NVIDIA Practice
Quantiphi
R&D Lead for Healthcare & Life Sciences
Quantiphi

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The Need For a Unified Omics Platform in the Era of Data Federation
  • Overview of XetaBase: a centralised genomic data analysis platform across research, clinical and multi-omics applications.
  • XetaBase’s advanced variant database and position as a gold-standard solution for tertiary analysis.
  • Launching a new application for data federation and its impacts on enhancing collaboration in research and clinical genomics.
  • Announcing the launch of XetaBase 3.0, which includes custom tool and workflow support, integrated notebooks, clinical variant database and our new SaaS deployment offering.
Speaker
Chief Commercial Officer
Zetta Genomics
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AI Can Transform Healthcare… But Not Until We Fix The Human Coordination Challenge
  • AI is advancing at an electrifying rate and transforming entire industries. But healthcare has traditionally been a digital laggard, can things be different this time? Yes - but only if we can solve the data silo problem and we think we know how...
Speaker
Chief Executive Officer
Velsera
[topic] INFRASTRUCTURE OPTIMISATION FOR RESEARCH AND HEALTHCARE
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A Digital Genomics Blueprint for Wales
  • Designing the national digital architecture to support the Genomics Partnership Wales
  • Addressing the complexity of EHR data
  • Overview of current projects and future directions
Speaker
Digital Architect
Digital Health and Care Wales
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Managing Peta-scale & Multi-modal Genomics Data Leveraging GenAI-infused Data Catalog
  • Latest technologies and innovations for managing large-scale and multi-modal datasets in genomics, following FAIR principles
  • Real-life healthcare and life sciences projects, including lessons learned and best practices
  • Live demos of data fabric, data sharing, and data orchestration
Speaker
Director & Distinguished Engineer
IBM WW Storage Technical Sales
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Sharing OMICs Data Internationally to Accelerate Biomedical Research
  • Reusing data in biomedical research – a paradigm shift
  • Types of OMICs data Sharing data from cancer genome projects
  • Secure sharing of OMIC data derived from patients
  • Building federated data-sharing infrastructure for the secure sharing of sensitive data
Speaker
EMBL Scientist Emeritus
EMBL-EBI
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[break] Break
  • Speed Networking: Fun and useful sessions where you’ll rapidly meet other Festival attendees to immediately expand your network
  • Food Options: Grab a sandwich at The Tree of Life Cafe or head on over to the Food Village for a range of hot food options, including Indian, Jamaican and Lebanese food
  • Exhibition Floor: Wander around the vibrant exhibition floor to see the latest technologies and services on offer
  • Talkaoke: The Flying Saucer of Chat, a fun and interactive pop-up show that offers you the opportunity to sit down with others and discuss any topic you like
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[topic] PANEL: INTERNATIONAL DATA SHARING
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Panel: How Can We Safely and Efficiently Share Data Internationally?

With the goal for many to be to share omics data internationally, what’s preventing the widespread sharing of data?

This panel will discuss:

  • The challenges of international data sharing, including infrastructure, data quality and security
  • Legal and ethical considerations
  • Lessons learned
Speakers
Director
Centro Nacional de Análisis Genómico (CNAG)
European Genomic Data Infrastructure Deployment Lead
ELIXIR Europe
All of Us Researcher and Participant
Team Lead- Genome Insights
CSIRO, Sydney, Australia