29th - 30th January 2025 | ExCeL, London
SINGLE CELL & SPATIAL STAGE
Biology at High Resolution
The Festival has a larger than ever focus on single cell & spatial with a stage devoted exclusively to 2 days of single cell and spatial presentations and panel discussions. Check out the agenda for the Single Cell & Spatial Stage below.
We also have a range of activities such as workshops and roundtables on single cell and spatial taking place at the Festival. Please see here for more information.
DAY 1
On Day 1, The Single-Cell & Spatial Stage will focus on single cell genomics, single cell multi-omics as well as single cell & spatial interrogation of cancer.
[topic] SINGLE-CELL GENOMICS
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Single Cell Genomics to Derive Quantitative Computational Models for Tissue Development
- Gastrulation and early organogenesis represents a key stage in mammalian development with relevance to developmental disorders and drug toxicities
- Small cell numbers and lack of cell purification protocols make single cell genomics method of choice for comprehensive molecular profiling
- Timecourse single cell genomics atlases represent important reference for analysis of developmental mutations
- Multispecies data enable comparative single cell genomics to assess cell type specific conservation of transcriptional programmes and predict "missing"
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More details to be announced shortly.
Sponsored by:
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Measuring Mutations and their Consequences Using Single-Cell Genomes
- Single-cell technology development and applications
- How somatic mosaicism contributes to inflammation-mediated diseases
- Modifying treatment outcomes using insights from single-cell comics
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[break] Lunch
- Exhibition Floor : Wander around the vibrant exhibition floor to see the latest technologies and services on offer
- Food Options : Grab a sandwich at The Tree of Life Cafe or head on over to the Food Village for a range of hot food options including Indian, Jamaican and Japanese food
- Live Lounge Over Lunch : 15 mins technology focussed presentations
- Poster Zone : Browse the posters and reach out to potential new collaborators
- Talkaoke : The Flying Saucer of Chat, a fun and interactive pop-up show that offers you the opportunity to sit down with others and discuss any topic you like.
- Patient Perspectives: Talks and discussions on the crucial role of patients and patient families in the understanding and development of treatments for rare diseases.
[topic] SINGLE-CELL MULTI-OMICS
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Single-Cell Analysis of Clonal Heterogeneity in Cancer
- Joint mRNA and whole-genome sequencing of single cells, across genetically diverse solid tumors and leukemias overcomes a fundamental challenge: how to study genetically distinct sub-clones, each supporting multiple stable cancer cell states, allowing us to analyze ongoing cancer evolution in patients, revealing common and disease-specific differences in the plasticity of genomes
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More details to be announced shortly.
Sponsored by:
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Multi-Scale Approaches for Patient Centric Analysis of Spatial-Multiomics
- Novel computational methods for multimodal spatial data integration of single cell
- Spatial transcriptomics and histology data tissue remodelling in myocardial infarction and kidney diseases
Speaker
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[break] Break
- Speed Networking: Fun and useful sessions where you’ll rapidly meet other Festival attendees to immediately expand your network.
- Food Options : Grab a coffee at The Tree of Life Cafe or head on over to the Food Village for a range of hot food options including Indian, Jamaican and Thai food
- Exhibition Floor : Wander around the vibrant exhibition floor to see the latest technologies and services on offer
- Talkaoke : The Flying Saucer of Chat, a fun and interactive pop-up show that offers you the opportunity to sit down with others and discuss any topic you like.
[topic] SINGLE-CELL & SPATIAL INTERROGATION OF CANCER
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Understanding Novel Cancer Drivers and Evolutionary Mechanisms at Spatial Resolution
- Using spatial technologies to study the interplay of extrinsic and intrinsic cancer drivers.
- The new translational opportunities brought from studying these cancer drivers at spatial resolution.
- Challenges, future opportunities and moving towards a multi omic approach.
Speaker
Lead
Centre for Cancer Genomics and Computational Biology, Barts Cancer Institute
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Sponsored Talk Available
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Cross-Species Single-Cell Analysis of Oral & Skin Shines Light into Fibroblast Heterogeneity in Scarless Healing Tissues
- Explore advanced spatial omics techniques to study the cellular dynamics involved in wound healing.
- Investigate differences in fibroblast behavior and healing processes between skin and oral mucosa, highlighting their role in scarless healing.
- Uncover fibroblast heterogeneity in scarless healing tissues through single-cell analysis across different species, providing insights into tissue regeneration.
DAY 2
The Single Cell & Spatial Stage will be focussing on integrating single cell and spatial multi-omics, spatial data analysis and overcoming data challenges of high resolution biology.
[topic] INTEGRATING SINGLE-CELL AND SPATIAL MULTI-OMICS
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Revealing the Landscape of Kidney Disease: a Multiomic & Spatial Approach to Renal Pathology
- Our current understanding of renal pathology is largely based on histological descriptors. As a consequence, for many kidney diseases, our diagnostic classifications do not adequately predict progression or response to treatment. To address this, and understand cellular disease mechanisms that can reveal new therapeutic targets, we need a new approach to interrogate renal disease at the cellular level.
- By integrating snRNA-seq and spatial methods in renal immune complex disease we can start to identify disease associated genes and pathways in tissue context. These insights provide a basis for functional validation, and potential integration into scalable clinical diagnostic and prognostic tools.
- New subcellular resolution spatial transcriptomics tools present new challenges in cell deconvolution and annotation. We have developed a topological data analysis approach to dynamically utilise the local transcriptomic context, and show that we can perform more accurate cell deconvolution across spatial platforms and tissues.
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Single-cell Phenoscaping of Tumour Microenvironment Organoids
- TOBis Mass Cytometry (TOBis MC) enables high-throughout single-cell phenotyping of heterocellular organoids
- We used TOBis MC to identify cancer associated fibroblast (CAF) regulation of colorectal cancer (CRC) patient-derived organoid drug responses
- CAFs protect CRC cells from therapy by inducing a revival stem cell state
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A Spatiotemporal Malignant Cell Trajectory Underlies Glioblastoma Heterogeneity
- Create single-cell level 3D maps of human organs using large-scale spatial transcriptomics
- Uncover the specialized functions of brain cell types using large-scale in vitro screens and mouse models
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[break] Lunch
- Exhibition Floor : Wander around the vibrant exhibition floor to see the latest technologies and services on offer
- Food Options : Grab a sandwich at The Tree of Life Cafe or head on over to the Food Village for a range of hot food options including Indian, Jamaican and Japanese food
- Live Lounge Over Lunch : 15 mins technology focussed presentations
- Poster Zone : Browse the posters and reach out to potential new collaborators
- Talkaoke : The Flying Saucer of Chat, a fun and interactive pop-up show that offers you the opportunity to sit down with others and discuss any topic you like.
[topic] SPATIAL DATA ANALYSIS
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Spatial Transcriptomics Identifies Molecular Signatures of Prodromal & Advanced Alpha-Synuclein Pathology in Parkinson Disease
- Spatial transcriptomics was applied for studying the transcriptomic changes in a mouse model of alpha-synucleinopathy at prodromal and advances stages of neuropathology
- Several of the key markers of neuronal stress response and pathological progression of alpha-synuclein aggregation were cross-validated in patient-derived microarray datasets and proteomics studies in cerebrospinal fluid
- These analyses are a rich source of information and hold promise for the discovery of novel biomarkers and/or targets for pharmacological
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Cell State Switches and Local Adaptation in Cancer: insights from Single Cell and Spatial Data
- The talk will cover different aspects of cell plasticity in cancer, such as the epithelial-to-mesenchymal transition.
- I will introduce some AI (language models)- based and ecology-inspired approaches developed in the group for single cell and spatial data, respectively, to capture plastic cell states and their interplay with the TME in cancer.
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Expanding the Toolkit for Spatial Omics Technologies
- Developing a new spatial technology with tuneable resolution and throughput.
- Combining single cell and multi-omics.
- Studying metastasis using high powered spatial technology.
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[break] Break
- Speed Networking : Fun and useful sessions where you’ll rapidly meet other Festival attendees to immediately expand your network.
- Food Options : Grab a coffee at The Tree of Life Cafe or head on over to the Food Village for a range of hot food options including Indian, Jamaican and Thai food
- Exhibition Floor : Wander around the vibrant exhibition floor to see the latest technologies and services on offer
- Talkaoke : The Flying Saucer of Chat, a fun and interactive pop-up show that offers you the opportunity to sit down with others and discuss any topic you like.
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PANEL: OVERCOMING DATA CHALLENGES OF HIGH RESOLUTION BIOLOGY
- What are the specific challenges posed by different single cell and spatial technologies? How do these challenges impact data quality, resolution, and interpretability?
- What are the computational and analytical challenges involved in integrating multiple single cell and spatial technologies?
- What are the emerging trends and future directions in single cell and spatial technologies? How can researchers stay ahead of the curve and incorporate these innovations into their experimental workflows?
Speakers