Background: The translation of genomic research into the NHS is rapidly evolving. To sustain this expansion, members of the workforce must be equipped with research and leadership skills to implement genomics in the NHS. Developing clinical academic fellowship roles that bridge research and service delivery is therefore critical to meeting this demand. We present six months of experience from the North East and Yorkshire (NEY) region with the first NHS Genomics Research Fellow embedded within the NEY Genomic Medicine Service (GMS). The fellowship was established to provide structured research time, mentorship, and training for a post-foundation doctor to lead on two NHS genomics research projects while gaining experience within the GMS infrastructure. To date, the post-holder is leading two research projects aligned to regional and national genomic priorities. The first focuses on the development and implementation of liquid biopsy testing in lung cancer, with the aim to improve service delivery in the NEY GMS. The second explores genomic chimerism testing strategies for bone marrow transplant recipients, with the aim of creating testing guidelines throughout the NEY region, which rationalise chimerism testing. In addition to research outputs, the fellowship facilitated training in bioinformatics, multidisciplinary collaboration, and exposure to clinical trial genomics.