PROTEOMICS STAGE

• Industry perspectives on how proteomics (and proteogenomics) is being used to advance drug discovery.
• Combing proteomics with human genetics-linked clinical data.
• Investigating system biology effects of genetic perturbations on the proteome.
• Identifying plasma proteomics biomarkers to inform disease risk and onset.
• What preclinical information and early disease signatures can be identified from the proteome?
• Current challenges and emerging opportunities for clinical proteomics.

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• Over the last three years, the applications of next-generation proteomics as a drug discovery and precision medicine tool have expanded exponentially.
• These expansions have been driven by increases in multiplexing, improved throughput, lower costs and targeted private – public investments, such as the UK Biobank Pharma Proteomics Project.
• This talk will outline how next-generation proteomics is set to expand even further, both in the short term (marked by even larger population-scale proteogenomics studies) and the medium term (marked by rapidly increased implementation in drug development and clinical settings

• Exhibition Floor : Wander around the vibrant exhibition floor to see the latest technologies and services on offer
• Food Options : Grab a sandwich at The Tree of Life Cafe or head on over to the Food Village for a range of hot food options including Indian, Jamaican and Thai food
• Live Lounge Over Lunch : 15 mins technology focussed presentations
• Poster Zone : Browse the posters and reach out to potential new collaborators
• Talkaoke : The Flying Saucer of Chat, a fun and interactive pop-up show that offers you the opportunity to sit down with others and discuss any topic you like.
• Patient Perspectives: Talks and discussions on the crucial role of patients and patient families in the understanding and development of treatments for rare diseases.

• Analysing big proteomics data in combination with genomics to improve understanding of disease aetiology
• Using proteomics to improve risk prediction for multiple diseases and biological ageing.
• Identifying repurposing or new targets from the circulating proteome
• Using proteomics to reveal mechanisms linking lifestyles with diseases.
  

• Circulating proteome
• Microsampling
• Molecular monitoring
• Health dynamics
  

• Speed Networking: Fun and useful sessions where you’ll rapidly meet other Festival attendees to immediately expand your network.
• Food Options : Grab a coffee and a cake at The Tree of Life Cafe or head on over to the Food Village for a range of hot food options including Indian, Jamaican and Thai food
• Exhibition Floor : Wander around the vibrant exhibition floor to see the latest technologies and services on offer
• Talkaoke : The Flying Saucer of Chat, a fun and interactive pop-up show that offers you the opportunity to sit down with others and discuss any topic you like.

• Using UKBB proteogenomic data to study associations between circulating proteins and cancer risk.
• Applications of clinical proteomics for therapeutic target discovery to support cancer prevention.
• Highlight the benefits of combining NGS with proteomics data from large prospective cohorts to identify cancer target proteins.
• Implementing these approaches in several national studies. 

• The identification of biomarkers on clinical samples (CSF/plasma) is crucial to differentiate between clinical severity, predict disease progression and help in prognosis and patient stratification
• The combination of new sample preparation strategies with developments in mass spectrometry is allowing to increase the proteomes depths and detect proteins beyond the acute phase response.