PROTEOMICS STAGE

• Industry perspectives on how proteomics (and proteogenomics) is being used to advance drug discovery.
• Combing proteomics with human genetics-linked clinical data.
• Investigating system biology effects of genetic perturbations on the proteome.
• Identifying plasma proteomics biomarkers to inform disease risk and onset.
• What preclinical information and early disease signatures can be identified from the proteome?
• Current challenges and emerging opportunities for clinical proteomics.

• Next-Generation Protein Sequencing™ on Platinum®, which significantly enhances the field of proteomics by providing deep insights into functional proteins encoded by the genome. We will discuss the single-molecule protein sequencing workflow that allows for precise protein identification and characterization across a wide range of sample types
• You’ll learn how this technology can distinguish proteoforms resulting from single amino acid changes, alternative splicing, and post-translational modifications
• We will also highlight our latest innovations, including the protein Barcoding Kit, which enables sample multiplexing for protein screening applications, and the Library Prep Kit, V2, which streamlines the preparation process, reducing hands-on time while improving data quality. Additionally, we’ll demonstrate how the integrated Platinum software unifies data generation and analysis, making the workflow both accessible and efficient for proteomic studies
• By the end of this session, you’ll understand how these new capabilities enable the seamless integration of proteomics into multi-omics research, opening new avenues for comprehensive biological insights

Key Takeaways:

• Single-molecule resolution workflow enables detailed protein identification and characterisation, including distinguishing proteoforms arising from mutations, alternative splicing, and post-translational modifications
• Protein Barcoding Kit enhances protein screening through multiplexed peptide barcoding, increasing efficiency and decreasing costs
• Library Prep Kit, V2 streamlines sample preparation, reduces required input, and enhances overall data quality, simplifying the integration of proteomics into multi-omics studies
  

• Over the last three years, the applications of next-generation proteomics as a drug discovery and precision medicine tool have expanded exponentially.
• These expansions have been driven by increases in multiplexing, improved throughput, lower costs and targeted private – public investments, such as the UK Biobank Pharma Proteomics Project.
• This talk will outline how next-generation proteomics is set to expand even further, both in the short term (marked by even larger population-scale proteogenomics studies) and the medium term (marked by rapidly increased implementation in drug development and clinical settings

• Exhibition Floor: Wander around the vibrant exhibition floor to see the latest technologies and services on offer
• Food Options: Grab a sandwich at The Tree of Life Cafe or head on over to the Food Village for a range of hot food options, including Indian, Jamaican and Lebanese food
• Live Lounge Over Lunch: 15-minute technology-focused presentations
• Poster Zone: Browse the posters and reach out to potential new collaborators
• Talkaoke: The Flying Saucer of Chat, a fun and interactive pop-up show that offers you the opportunity to sit down with others and discuss any topic you like

• Analysing big proteomics data in combination with genomics to improve understanding of disease aetiology
• Using proteomics to improve risk prediction for multiple diseases and biological ageing.
• Identifying repurposing or new targets from the circulating proteome
• Using proteomics to reveal mechanisms linking lifestyles with diseases.
  

• Circulating proteome
• Microsampling
• Molecular monitoring
• Health dynamics
  

• Speed Networking: Fun and useful sessions where you’ll rapidly meet other Festival attendees to immediately expand your network
• Food Options: Grab a coffee and a cake at The Tree of Life Cafe or head on over to the Food Village for a range of hot food options, including Indian, Jamaican and Lebanese food
• Exhibition Floor: Wander around the vibrant exhibition floor to see the latest technologies and services on offer
• Talkaoke: The Flying Saucer of Chat, a fun and interactive pop-up show that offers you the opportunity to sit down with others and discuss any topic you like

• Using UKBB proteogenomic data to study associations between circulating proteins and cancer risk.
• Applications of clinical proteomics for therapeutic target discovery to support cancer prevention.
• Highlight the benefits of combining NGS with proteomics data from large prospective cohorts to identify cancer target proteins.
• Implementing these approaches in several national studies. 

• How can a herpes drug bind to a cancer target?
• Drug targets share similar binding pockets, an unwanted side effect can be beneficial in other contexts
• I will show algorithms, examples, and experimental validation of structure-based drug repositioning covering cancer, Chagas, and auto-immune disease